Science News Fibroblasts could provide new target for treatment of rheumatoid arthritis Date: University of Birmingham Summary: A new study reveals the key role of different types of fibroblast cells in the development of rheumatoid arthritis (RA), opening up a new avenue for research into treatment of the disease. go to this siteSynovial Fibroblasts (SFs) are cells that make up part of the connective tissue, or synovium, around human joints. In RA patients, SF cells cause damage by invading and attacking the cartilage and bone around the joint. Synovial Fibroblasts (SFs) are cells that make up part of the connective tissue, or synovium, around human joints. In RA patients, SF cells cause damage by invading and attacking the cartilage and bone around the joint. A team of researchers from the University of Birmingham’s Institute of Inflammation and Ageing identified two distinct types of SF within the synovial membrane. The team showed that these cell types, defined by the presence of specific cell surface markers (PDPN and CD248), aggregate in different layers of the synovium, and just one (the PDPN type) is responsible for cartilage damage in RA patients. During the study, SF cells from RA patients were grown in vitro within an artificial synovium, then ‘activated’ using stress-inducing proteins called cytokines. The artificial synovium containing the SFs was then inserted into a mouse (whose own immune system had been ‘switched off’), along with human cartilage to simulate a joint, to see how the SF cells would develop in vivo. Following implantation, tests showed that the ‘lining’ layer of the artificial synovium (i.e.
For the original version including any supplementary images or video, visit https://www.sciencedaily.com/releases/2016/11/161123142844.htm
Tea tree oil consists of naturally occurring organic chemicals called terpenoids, which have antiseptic and anti fungal properties. Honey can make it more effective and palatable. In severe cases, the patient might have to be admitted in an ICU and placed on a ventilator. ➠ Hospitalization might be needed for children with symptoms such as dehydration, excessive sleepiness, breathing problems, low blood oxygen levels, and low body temperature. ➠ Besides antibiotics/antivirals, drugs such as antipyretics fever reducers, expectorants for loosening cough, and non-steroidal anti-inflammatory drugs might be prescribed. ➠ Besides drug therapy, following self-care measures such as staying hydrated and taking ample rest will also prove beneficial. ➠ If the contributing factor for lung inflammation is hypersensitivity pneumonitis inhalation of an allergen, exposure to chemicals, or a drug reaction, then the offending substance must be avoided. Acute gastritis can be relieved by discontinuing the use of those substances which are responsible for inflamed stomach. Sacroiliac joint dysfunction can never be completely cured, however, with good management that includes maintaining a good body weight, healthy diet, physical therapy, and medication, it is possible to alleviate pain, and lead a normal healthy life. Ibuprofen can irritate the stomach but considering its effective anti-inflammatory properties, taking it in small doses can help to provide maximum arthritis pain relief with minimum, well tolerable side effects. Alter your habit of having coffee, by drinking green tea as it contains some antioxidants which are beneficial for the overall health of the body. To neutralize the effect of acids, antacids such as Mylanta and Maalox are prescribed. Stay fit! These precautions will reduce the chances of complications and will help you to recover fast. http://www.alabamascholars.org/carsonpetersonart/2016/11/09/tips-for-2015-on-smart-methods-for-inflammation-in-ankle/